Jiménez-Saiz Lab

 

Team members 

Rodrigo Jiménez-Saiz

Dept. of Immunology, IIS-IP 

Hospital Universitario de La Princesa

Diego de León 62, 28006, Madrid Spain 

 

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PhD: Universidad Autónoma de Madrid, Madrid, Spain, 2008 - 2012


Postdoc: McMaster Immunology Research Centre (MIRC), Hamilton, Canada, 2012 - 2017

Immunology Instructor: Faculty of Health Sciences,  McMaster University, Hamilton, Canada, 2013 - 2018


Research Associate Academic: MIRC, Hamilton, Canada, 2017 - 2018

Assistant Professor (part-time): Dept. of Pathology & Molecular Medicine, McMaster University, Hamilton, Canada, since 2019 

Associate Professor (part-time): Faculty of Experimental Sciences, Universidad Francisco de Vitoria, Madrid, Spain, since 2019 

Juan de La Cierva Researcher: Dept. of Immunology & Oncology, CNB-CSIC, Madrid, Spain, 2018 - 2020

Junior Group Leader: Dept. of Immunology & Oncology, CNB-CSIC, Madrid, Spain, 2020 - 2021

Miguel Servet Principal Investigator: Dept. of Immunology, IIS-IP, Hospital Universitario de La Princesa Madrid, Spain, since 2021

Domenico Rosace

Dept. of Immunology, IIS-IP 

Hospital Universitario de La Princesa

Diego de León 62, 28006, Madrid Spain 

 

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I did my undergraduate in "Medical Biotechnology" at the University of Naples (Italy). I completed my training in pharmaceutical biotechnology at the ALMA Mater University in Bologna (Italy). In both Universities I acquired a great interest in the pharmaceutical field applied to human health and my desire to continue my career in research.

In 2013, through the Erasmus Placement grant, I spent 7 months in the Medical Oncology laboratory of the VU University Medical Center Amsterdam (The Netherlands), where I developed an oncology project under the supervision of Dr. Elisa Giovannetti.

In 2014, enjoying an FPI pre-doctoral fellowship, I started my PhD in Translational Medicine and Immunology at the Institute of Applied Molecular Medicine at the San Pablo CEU University School of Medicine in Madrid (Spain). I worked on several research projects on Th2 immunity and allergy; the main one centered on the study of cross-reactivity between aeroallergens and food allergens.

Enjoying an international mobility scholarship sponsored by Santander bank, I did a 6-month stay at McMaster University (Canada) under the supervision of Dr. Rodrigo Jiménez-Saiz. There I studied the contribution of IgG+ B cells in the incipient stages of epicutaneous sensitization to food. This stay gave me the opportunity to grow professionally, gaining experience in pre-clinical models and consolidating my knowledge in immunology.

In 2020 I was hired as a postdoctoral researcher at the Cancer Research Center of Salamanca (Spain) where I obtained a "Juan de la Cierva Formación" postdoctoral grant. 

 

Since December 2020 I have been a visiting researcher at the National Center for Biotechnology (CNB, Spain) in the Jiménez-Saiz lab focusing on different projects related to Th2 Immunity and allergy.

Celia López Sanz

Dept. of Immunology, IIS-IP 

Hospital Universitario de La Princesa

Diego de León 62, 28006, Madrid Spain

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I completed a BSc in Biochemistry at the Universidad Autónoma de Madrid (Spain) in 2018, and I am currently an Immunology Intern at the Hospital Universitario de La Princesa.
 
I took my first steps in science in the last year of college, when I performed my end-of-degree project about the pre-TCR signaling pathway and its possible implication in T acute lymphoblastic leukaemia (T-ALL) at the Centro de Biología Molecular Severo Ochoa (CBMSO). 
 
After that, I started my studies in the clinical setting and I am currently working as an Immunology Intern at the Hospital Universitario de La Princesa. In the course of my internship the multidisciplinary research caught my attention. For that reason, I got interested in Dr. Jiménez-Saiz’s research lines and decided to begin my PhD in his group.

Nieves Fernández

Dept. of Vascular Pathophysiology

CNIC

Melchor Fernández Almagro 3
28029 Madrid,

Spain

 

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I graduated in Biochemistry at Universidad de Granada (Spain) in 2016. Then I moved to Madrid to complete a MSc in Molecular Biomedicine at the Universidad Autónoma de Madrid (Spain).

My master’s project was under the supervision of Dr. Pilar Martín at CNIC with a Research Scholarship for Master students from CNIC. My work focused on studying experimental autoimmune myocarditis in mice with mitochondrial alterations. During this period I became very interested in immunology, metabolism and cardiovascular disease.

 

Currently, I am doing a PhD in Molecular Bioscience with a FPU grant in Sánchez-Madrid´s Lab. My PhD work is focused in immunometabolism of amino acid transporters but I also collaborate in projects about psoriasis, contact dermatitis and allergy, the latter with the Jiménez-Saiz Lab.

Elisa Sánchez Martínez

I am an undergraduate Biology student at the Universidad Complutense de Madrid (UCM, Spain). I am currently studying the last year of the degree, doing the health specialty.

I have been interested in different projects related to nutrition and antibiotic resistance. Hence, I participated in activities related to this topic organized by the Consejo Superior de Investigaciones Científicas (CSIC, Spain) and collaborated with the Small World Initiative (SWI) Project.

Immunology has always been one of my curiosities. I met Dr. Jiménez-Saiz doing biochemistry laboratory, which prompted me to choose his group for beginning to develop myself as a scientist. In the future, I would like to be a researcher, focusing my studies in clinical immunology.
 

Dept. of Immunology, IIS-IP 

Hospital Universitario de La Princesa

Diego de León 62, 28006, Madrid Spain 

 

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  Research

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Our goal is to understand immunological principles of Th2 immunity in the context of allergic disease, particularly as it pertains to acute allergic reactions (anaphylaxis) and its modulation by the microbiota, the maintenance of IgE immunity (memory responses), and the impact of allergic disease in the development of other pathologies. 

Our lab has a marked translational identity, which has been achieved through research in pre-clinical models of allergic disease and a close collaboration with clinicians. 

We are constantly seeking for new members that are highly motivated and have strong critical thinking skills!

Collaborators

Drs. Alberto Caminero, Elena F. VerdúManel Jordana, McMaster University, Hamilton, Canada

 

Drs. Franscico Sánchez-Madrid & Carlos Blanco, Hospital Universitario de La Princesa, Madrid, Spain

Drs. Wayne G. Shreffler and Sarita U. Patil, Massachusetts General Hospital, Boston, USA

Dr. Yolanda R. Carrasco, CNB-CSIC, Madrid, Spain

Dr. F. Javier Moreno, CIAL-CSIC, Madrid, Spain

Drs. Domingo Barber & María M. Escribese IMMA, Madrid, Spain

 

Funding Sources

 

Publications 

Full publication list 

 

Google Scholar

ResearchGate

ORCID 

publons 

McMaster Experts 

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Selected Publications 

Jiménez-Saiz R, et al.  Microbial Regulation of enteric eosinophils and its impact in Th2 immunity and tissue remodelingFrontiers in Immunology, 2020, 11:55

Jiménez-Saiz R, et al.  Human BCR analysis of single-sorted IgE+ memory B cells in food allergy. Journal of Allergy and Clinical Immunology, 2019, 144:336

Jiménez-Saiz R, et al. The IgE memory reservoir in food allergy. Journal of Allergy and Clinical Immunology, 2018, 142:1441

Ellengbogen  Y,  Jiménez-Saiz R, et al. The initiation of Th2 immunity towards food allergens. International Journal of Molecular Sciences, 2018, 19:1447

Jiménez-Saiz R, et al. IgG1+ B cell immunity predates IgE responses in  epicutaneous sensitization to foods. Allergy, 2018, 74:165

Jiménez-Saiz R, et al. Initiation, persistence and exacerbation of food allergy. In: Allergy Prevention and Exacerbation, 121-144. Springer. ISBN: 978-3-319-69967-7

Jiménez-Saiz R, et al. Lifelong memory responses perpetuate humoral Th2 immunity and anaphylaxis in food allergy. Journal of Allergy and Clinical Immunology, 2017, 140:1604

Chu DK, Mohammed-Ali Z, Jiménez-Saiz R, et al. T helper cell IL-4 drives intestinal Th2 priming to oral peanut antigen, under the control of OX40L and independent of innate-like lymphocytes. Mucosal Immunology, 2014, 7:1395

Chu DK, Jiménez-Saiz R, et al. Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo. Journal of Experimental Medicine, 2014, 211:1657

 

Lab News

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June 2021

- We are very thankful to the SEAIC Foundation for supporting our project on effector cell neuromodulation in allergic disease with a research grant 

- Congratulations to Regina Rubira for successfully completing her Bachelor´s Thesis

 

May 2021

- New review, in collaboration with the Jordana Lab at McMaster University, published in Immunotargets & Therapy: Memory Generation and Re-Activation in Food Allergy

April 2021

- Rodrigo gave an invited talk at the CBGP UPM-INIA seminars

March 2021

- New preprint: Memory Generation and Re-Activation in Food Allergy

- Rodrigo gave an oral presentation at the Basic Immunology and Innate Immunity session of the 42nd Congress of the Spanish Society of Immunology (SEI)

 

February 2021

- New preprint: Oral Immunotherapy for Food-Allergic Children: A Pro-Con Debate

- Rodrigo has joined the Editorial Board of Frontiers in Immunology!

January 2021

- We were awarded a grant from The Nutricia Research Foundation to investigate microbiota and anaphylaxis together with Alberto Caminero (McMaster University)

December 2020 

- New article: Interrupting reactivation of immunological memory diverts the allergic response and prevents anaphylaxis in The Journal of Allergy and Clinical Immunology

November 2020 

- New editorial in AllergyEnlightening human B‐cell diversity

October 2020 

- Rodrigo attended the Food Allergy and Anaphylaxis Meeting (FAAM)-EUROBAT Digital as a member of the Scientific Committee. He gave 2 invited talks and moderated one symposium  

- Rodrigo received the Allergy's Distiguished Reviewer Award

- New editorial in AllergySingle‐cell RNA analysis: Guiding the treatment of DiHS/DRESS

September 2020 

- Congratulations to María Cottereau for successfully completing her Bachelor´s Thesis

- New editorial in Allergy: The neuroimmunological toll of nutrient absorption 

August 2020 

- New editorial in Allergy: Thinking small: Zinc sensing by the gut epithelium

July 2020 

- New reviews on SARS-CoV-2 and COVID-19 in Allergy:

A compendium answering 150 questions on COVID-19 and SARS-CoV-2

 

Immunology of COVID‐19: mechanisms, clinical outcome, diagnostics and perspectives – a report of the European Academy of Allergy and Clinical Immunology (EAACI)

June 2020 

Rodrigo received the EAACI Allergopharma Reserch Award  at the EAACI Annual Congress 2020 where he gave an invited talk entitled "Route of exposure determines the immune response to food allergens"

April 2020 

- Alberto Caminero (McMaster University) and Rodrigo were awarded a New Frontiers in Research Fund – Exploration 2019 grant

March 2020 

- New article, on B cell biology,  through a collaboration with Drs. Ana Cuenda and Yolanda R. Carrasco at CNB-CSIC:  B Cell Development and T-Dependent Antibody Response Are Regulated by p38γ and p38δ  in Frontiers in Cell & Developmental Biology

New editorial: Follicular T cells: from stability to failure in Allergy 

February 2020 

- New article: Microbial Regulation of Enteric Eosinophils and Its Impact on Tissue Remodeling and Th2 Immunity in Frontiers in Immunology

New editorial: Drug‐induced IgG‐neutrophil‐mediated anaphylaxis in humans: Uncovered! in Allergy 

January 2020 

- Rodrigo has joined the Editorial Board of Allergy!

- Rodrigo attended the 18th Immunology Winter Immunology School in Chamonix (France) as Junior Member Representative of the Immunology Section of EAACI.

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Location

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Dept. of Immunology, IIS-IP

Hospital Universitario de La Princesa

C/ Diego de León, 28006, Madrid

Spain​​​

©2020 by Jiménez-Saiz Lab