Jiménez-Saiz Lab

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Team members 

Rodrigo Jiménez-Saiz

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Dept. of Immunology, IIS-Princesa 

Hospital Universitario de La Princesa

Diego de León 62, 28006, Madrid Spain 

 

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PhD: Universidad Autónoma de Madrid, Madrid, Spain, 2008 - 2012


Postdoc: McMaster Immunology Research Centre (MIRC), Hamilton, Canada, 2012 - 2017

Immunology Instructor: Faculty of Health Sciences,  McMaster University, Hamilton, Canada, 2013 - 2018


Research Associate Academic: MIRC, Hamilton, Canada, 2017 - 2018

Assistant Professor (part-time): Dept. of Medicine, McMaster University, Hamilton, Canada, since 2019 

Associate Professor (part-time): Faculty of Experimental Sciences, Universidad Francisco de Vitoria, Madrid, Spain, since 2019 

Juan de La Cierva Researcher: Dept. of Immunology & Oncology, CNB-CSIC, Madrid, Spain, 2018 - 2020

Junior Group Leader: Dept. of Immunology & Oncology, CNB-CSIC, Madrid, Spain, 2020 - 2021

Miguel Servet Principal Investigator: Dept. of Immunology, IIS-IP, Hospital Universitario de La Princesa Madrid, Spain, since 2021

Celia López Sanz

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I completed a BSc in Biochemistry at the Universidad Autónoma de Madrid (Spain) in 2018, and I am currently an Immunology Intern at the Hospital Universitario de La Princesa.
 
I took my first steps in science in the last year of college, when I performed my end-of-degree project about the pre-TCR signaling pathway and its possible implication in T acute lymphoblastic leukaemia (T-ALL) at the Centro de Biología Molecular Severo Ochoa (CBMSO). 
 
After that, I started my studies in the clinical setting and I am currently working as an Immunology Intern at the Hospital Universitario de La Princesa. In the course of my internship the multidisciplinary research caught my attention. For that reason, I got interested in Dr. Jiménez-Saiz’s research lines and decided to begin my PhD in his group.

Dept. of Immunology, IIS-Princesa 

Hospital Universitario de La Princesa

Diego de León 62, 28006, Madrid Spain

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Nieves Fernández

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I graduated in Biochemistry at Universidad de Granada (Spain) in 2016. Then I moved to Madrid to complete a MSc in Molecular Biomedicine at the Universidad Autónoma de Madrid (Spain).

My master’s project was under the supervision of Dr. Pilar Martín at CNIC with a Research Scholarship for Master students from CNIC. My work focused on studying experimental autoimmune myocarditis in mice with mitochondrial alterations. During this period I became very interested in immunology, metabolism and cardiovascular disease.

 

Currently, I am doing a PhD in Molecular Bioscience with a FPU grant in Sánchez-Madrid´s Lab. My PhD work is focused in immunometabolism of amino acid transporters but I also collaborate in projects about psoriasis, contact dermatitis and allergy, the latter with the Jiménez-Saiz Lab.

Dept. of Vascular Pathophysiology

CNIC

Melchor Fernández Almagro 3
28029 Madrid,
Spain

 

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Elisa Sánchez Martínez

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I am an undergraduate Biology student at the Universidad Complutense de Madrid (UCM, Spain). I am currently studying the last year of the degree, doing the health specialty.

I have been interested in different projects related to nutrition and antibiotic resistance. Hence, I participated in activities related to this topic organized by the Consejo Superior de Investigaciones Científicas (CSIC, Spain) and collaborated with the Small World Initiative (SWI) Project.

Immunology has always been one of my curiosities. I met Dr. Jiménez-Saiz doing biochemistry laboratory, which prompted me to choose his group for beginning to develop myself as a scientist. In the future, I would like to be a researcher, focusing my studies in clinical immunology.
 

Dept. of Immunology, IIS-Princesa 

Hospital Universitario de La Princesa

Diego de León 62, 28006, Madrid Spain 

 

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Paula Hernández Ruíz

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I graduated in Biotechnology in 2020, at the University of Barcelona (Spain). I went to the University of Padua (Italy) to develop my end-of-degree project. It was focused on cellular bioenergetics in the pathways of mitochondria and Ca2+ tethering. We were also developing a new organelle proximity sensor (SPLICS).


Then, I took a Research Master in Translational Medicine, specialized in neurologic diseases at UCM (Spain). My end-of-master project was carried at the Neuroscience and Mental Health Dept. of the 12th of October Hospital (Dr. Bartolome´s lab). It was focused on SORL1 mutation in humans with Alzheimer’s Disease.

Now, I am studying a Master in Clinical Trials Monitoring at CESIF; but as I want to follow the research pathway I started looking for a laboratory that centers its attention on translational research and joined Dr. Jimenez-Saiz’s lab.

Dept. of Immunology, IIS-Princesa 

Hospital Universitario de La Princesa

Diego de León 62, 28006, Madrid Spain 

 

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  Research

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Our goal is to understand immunological principles of type 2 immunity in the context of allergic disease, particularly as it pertains to acute allergic reactions and its modulation by the microbiota, mast cell-neuron communication, and the impact of allergic disease in the development of atherosclerosis. 

Our lab has a marked translational identity, which has been achieved through research in pre-clinical models of allergic disease and a close collaboration with clinicians. 

We are constantly seeking for new members that are highly motivated and have strong critical thinking skills!

Collaborators

Drs. Alberto Caminero & Manel Jordana, McMaster University, Hamilton, Canada

 

Drs. Franscico Sánchez-Madrid & Carlos Blanco, Hospital Universitario de La Princesa, Madrid, Spain

Drs. Vanesa Esteban & Joaquín Sastre, Fundación Jiménez Diaz, Madrid, Spain 

Drs. Wayne G. Shreffler and Sarita U. Patil, Massachusetts General Hospital, Boston, USA

Dr. Yolanda R. Carrasco, CNB-CSIC, Madrid, Spain

Dr. F. Javier Moreno, CIAL-CSIC, Madrid, Spain

Drs. Domingo Barber & María M. Escribese IMMA, Madrid, Spain

Funding Sources

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Publications 

Full publication list 

 

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ResearchGate

ORCID 

publons 

McMaster Experts 

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Selected Publications 

Fernández-Gallego N, Castillo-González R et al. [...] Jiménez-Saiz R*. The impact of type 2 immunity and allergic diseases in atherosclerosis. Allergy, 2022, doi:10.1111/all.15426

Riggioni C, Comberiati and Giovannini M et al. [...] Jiménez-Saiz R* & Akdis CA*A compendium answering 150 questions on COVID-19 and SARS-CoV-2. Allergy, 2020, 75:2503-2541

 

Jiménez-Saiz R, et al.  Microbial Regulation of enteric eosinophils and its impact in Th2 immunity and tissue remodelingFrontiers in Immunology, 2020, 11:55

Jiménez-Saiz R, et al.  Human BCR analysis of single-sorted IgE+ memory B cells in food allergy. Journal of Allergy and Clinical Immunology, 2019, 144:336

Jiménez-Saiz R, et al. The IgE memory reservoir in food allergy. Journal of Allergy and Clinical Immunology, 2018, 142:1441

Ellengbogen  Y,  Jiménez-Saiz R, et al. The initiation of Th2 immunity towards food allergens. International Journal of Molecular Sciences, 2018, 19:1447

Jiménez-Saiz R, et al. IgG1+ B cell immunity predates IgE responses in  epicutaneous sensitization to foods. Allergy, 2018, 74:165

Jiménez-Saiz R, et al. Initiation, persistence and exacerbation of food allergy. In: Allergy Prevention and Exacerbation, 121-144. Springer. ISBN: 978-3-319-69967-7

Jiménez-Saiz R, et al. Lifelong memory responses perpetuate humoral Th2 immunity and anaphylaxis in food allergy. Journal of Allergy and Clinical Immunology, 2017, 140:1604

Chu DK, Mohammed-Ali Z, Jiménez-Saiz R, et al. T helper cell IL-4 drives intestinal Th2 priming to oral peanut antigen, under the control of OX40L and independent of innate-like lymphocytes. Mucosal Immunology, 2014, 7:1395

Chu DK, Jiménez-Saiz R, et al. Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo. Journal of Experimental Medicine, 2014, 211:1657

 

Lab News

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August 2022

-- We are very thankful to the ISCIII for supporting our project on the impact of allergic disease in atherosclerosis with a research grant

July 2022

-- Invited review published in AllergyThe impact of type 2 immunity and allergic diseases in atherosclerosis

June 2022

Invited review published in Frontiers in Allergy: Mast Cell Desensitization in Allergen Immunotherapy

- Congratulations to Elisa Sánchez Martínez for successfully defending her Bachelor´s Thesis

May 2022

-- Rodrigo gave an invited talk on the immunological relationship between the skin and allergic disease at the 2nd congress of the Sociedad Catalana de Alergia e Inmunología Clínica (SCAIC) in Barcelona (Spain)

April 2022

-- New collaborative article, published in PLoS Pathogens: Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infection

March 2022

Rodrigo has joined the section Therapies, Therapeutic Targets & Mechanisms of Frontiers in Allergy as Associate Editor

February 2022

-- New collaborative article, published in the European Respiratory Journal: Cigarette smoke augments CSF3 expression in neutrophils to compromise alveolar-capillary barrier function during influenza infection

January 2022

Rodrigo attended the 20th Immunology Winter Immunology School - Digital as Junior Member Representative of the Immunology Section of EAACI

 

December 2021

-- New article: The cannabinoid WIN55212-2 impairs peanut allergic sensitization and promotes the generation of allergen-specific regulatory T cells in Clinical & Experimental Allergy

November 2021

-- Rodrigo gave an educational lecture entitled "The allergic immune response for beginners" for the Scientific Basis of Allergy module of the Allergy MSc programme at the Imperial College (UK)

October 2021

-- Rodrigo gave an invited talk on the mechanisms underlying persistent allergy at the 3rd meeting of the food allergy interest group (ALiADOS) at the 33rd annual congress of SEAIC in Zaragoza (Spain)

 

September 2021

-- New collaborative review, published in Frontiers in ImmunologyOral Immunotherapy for Food-Allergic Children: A Pro-Con Debate

August 2021

-- New editorial in AllergyLocal inflammation enables a basophil-neuronal circuITCH in atopic dermatitis

 

July 2021

- Rodrigo gave an invited talk entitled "Understanding immunological mechanisms that confer a higher risk of allergy" at the JMA Scientific Symposium of the EAACI Hybrid Congress 2021

June 2021

- We are very thankful to the SEAIC Foundation for supporting our project on effector cell neuromodulation in allergic disease with a research grant 

- Congratulations to Regina Rubira for successfully completing her Bachelor´s Thesis

 

May 2021

- New review, in collaboration with the Jordana Lab at McMaster University, published in Immunotargets & Therapy: Memory Generation and Re-Activation in Food Allergy

April 2021

- Rodrigo gave an invited talk at the CBGP UPM-INIA seminars

March 2021

- New preprint: Memory Generation and Re-Activation in Food Allergy

- Rodrigo gave an oral presentation at the Basic Immunology and Innate Immunity session of the 42nd Congress of the Spanish Society of Immunology (SEI)

 

February 2021

- New preprint: Oral Immunotherapy for Food-Allergic Children: A Pro-Con Debate

- Rodrigo has joined the Editorial Board of Frontiers in Immunology!

January 2021

- We were awarded a grant from The Nutricia Research Foundation to investigate microbiota and anaphylaxis together with Alberto Caminero (McMaster University)

December 2020 

- New article: Interrupting reactivation of immunological memory diverts the allergic response and prevents anaphylaxis in The Journal of Allergy and Clinical Immunology

November 2020 

- New editorial in AllergyEnlightening human B‐cell diversity

October 2020 

- Rodrigo attended the Food Allergy and Anaphylaxis Meeting (FAAM)-EUROBAT Digital as a member of the Scientific Committee. He gave 2 invited talks and moderated one symposium  

- Rodrigo received the Allergy's Distinguished Reviewer Award

- New editorial in AllergySingle‐cell RNA analysis: Guiding the treatment of DiHS/DRESS

September 2020 

- Congratulations to María Cottereau for successfully completing her Bachelor´s Thesis

- New editorial in Allergy: The neuroimmunological toll of nutrient absorption 

August 2020 

- New editorial in Allergy: Thinking small: Zinc sensing by the gut epithelium

July 2020 

- New reviews on SARS-CoV-2 and COVID-19 in Allergy:

A compendium answering 150 questions on COVID-19 and SARS-CoV-2

 

Immunology of COVID‐19: mechanisms, clinical outcome, diagnostics and perspectives – a report of the European Academy of Allergy and Clinical Immunology (EAACI)

June 2020 

Rodrigo received the EAACI Allergopharma Reserch Award  at the EAACI Annual Congress 2020 where he gave an invited talk entitled "Route of exposure determines the immune response to food allergens"

April 2020 

- Alberto Caminero (McMaster University) and Rodrigo were awarded a New Frontiers in Research Fund – Exploration 2019 grant

March 2020 

- New article, on B cell biology,  through a collaboration with Drs. Ana Cuenda and Yolanda R. Carrasco at CNB-CSIC:  B Cell Development and T-Dependent Antibody Response Are Regulated by p38γ and p38δ  in Frontiers in Cell & Developmental Biology

New editorial: Follicular T cells: from stability to failure in Allergy 

February 2020 

- New article: Microbial Regulation of Enteric Eosinophils and Its Impact on Tissue Remodeling and Th2 Immunity in Frontiers in Immunology

New editorial: Drug‐induced IgG‐neutrophil‐mediated anaphylaxis in humans: Uncovered! in Allergy 

January 2020 

- Rodrigo has joined the Editorial Board of Allergy!

- Rodrigo attended the 18th Immunology Winter Immunology School in Chamonix (France) as Junior Member Representative of the Immunology Section of EAACI.

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Location

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Dept. of Immunology, IIS-Princesa

Hospital Universitario de La Princesa

C/ Diego de León, 28006, Madrid

Spain​​​

©2020 by Jiménez-Saiz Lab