Type 2 Immunity & Allergy

©2020 by Jiménez-Saiz Lab

Rodrigo Jiménez-Saiz


Dept. Immunology & Oncology


Darwin 3, 28049, Madrid, Spain 



PhD: Universidad Autónoma de Madrid, Madrid, Spain, 2008 - 2012

Postdoc: McMaster Immunology Research Centre (MIRC), Hamilton, Canada, 2012 - 2017

Immunology Instructor: Faculty of Health Sciences,  McMaster University, Hamilton, Canada, 2013 - 2018

Research Associate Academic: MIRC, Hamilton, Canada, 2017 - 2018

Assistant Professor (part-time): Dept. of Pathology & Molecular Medicine, McMaster University, Hamilton, Canada, since 2019 

Associate Professor (part-time): Faculty of Experimental Sciences, Universidad Francisco de Vitoria, Madrid, Spain, since 2019 

Juan de La Cierva Researcher: Dept. of Immunology & Oncology, CNB-CSIC, Madrid, Spain, 2018 - 2020

Junior Group Leader: Dept. of Immunology & Oncology, CNB-CSIC, Madrid, Spain, since 2020

email logo.jfif
Phone logo.jpg



Our goal is to understand immunological principles of Th2 immunity in the context of allergic disease, particularly as it pertains to acute allergic reactions (anaphylaxis) and its modulation by the microbiota, the maintenance of IgE immunity (memory responses), and the impact of allergic disease in the development of other pathologies. 

Our lab has a marked translational identity, which has been achieved through research in pre-clinical models of allergic disease and a close collaboration with clinicians. 

We are constantly seeking for new members that are highly motivated and have strong critical thinking skills!


Drs. Alberto Caminero, Elena F. Verdú & Manel Jordana, McMaster University, Hamilton, Canada


Drs. Franscico Sánchez-Madrid & Carlos Blanco, Hospital Universitario La Princesa, Madrid, Spain

Drs. Wayne Shreffler and Sarita U. Patil, Massachusetts General Hospital, Boston, USA

Dr. Yolanda R. Carrasco, CNB-CSIC, Madrid, Spain

Dr. F. Javier Moreno, CIAL-CSIC, Madrid, Spain

Drs. Domingo Barber, IMMA, Madrid, Spain

Funding Sources

Nutricia Research.jpg


Full publication list 


Google Scholar




McMaster Experts 


Selected Publications 

Jiménez-Saiz R, et al.  Microbial Regulation of enteric eosinophils and its impact in Th2 immunity and tissue remodelingFrontiers in Immunology, 2020, 11:55

Jiménez-Saiz R, et al.  Human BCR analysis of single-sorted IgE+ memory B cells in food allergy. Journal of Allergy and Clinical Immunology, 2019, 144:336

Jiménez-Saiz R, et al. The IgE memory reservoir in food allergy. Journal of Allergy and Clinical Immunology, 2018, 142:1441

Ellengbogen  Y,  Jiménez-Saiz R, et al. The initiation of Th2 immunity towards food allergens. International Journal of Molecular Sciences, 2018, 19:1447

Jiménez-Saiz R, et al. IgG1+ B cell immunity predates IgE responses in  epicutaneous sensitization to foods. Allergy, 2018, 74:165

Jiménez-Saiz R, et al. Initiation, persistence and exacerbation of food allergy. In: Allergy Prevention and Exacerbation, 121-144. Springer. ISBN: 978-3-319-69967-7

Jiménez-Saiz R, et al. Lifelong memory responses perpetuate humoral Th2 immunity and anaphylaxis in food allergy. Journal of Allergy and Clinical Immunology, 2017, 140:1604

Chu DK, Mohammed-Ali Z, Jiménez-Saiz R, et al. T helper cell IL-4 drives intestinal Th2 priming to oral peanut antigen, under the control of OX40L and independent of innate-like lymphocytes. Mucosal Immunology, 2014, 7:1395

Chu DK, Jiménez-Saiz R, et al. Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo. Journal of Experimental Medicine, 2014, 211:1657


Lab News

  • Twitter

January 2021

- We have been awarded a grant from The Nutricia Research Foundation to investigate microbiota and anaphylaxis together with Alberto Caminero (McMaster University)

December 2020 

- New article: Interrupting reactivation of immunological memory diverts the allergic response and prevents anaphylaxis in The Journal of Allergy and Clinical Immunology

November 2020 

- New editorial in AllergyEnlightening human B‐cell diversity

October 2020 

- Rodrigo attended the Food Allergy and Anaphylaxis Meeting (FAAM)-EUROBAT Digital as member of the Scientific Committee. He gave 2 invited talks and moderated one symposium  

- Rodrigo received the Allergy's Distiguished Reviewer Award

- New editorial in AllergySingle‐cell RNA analysis: Guiding the treatment of DiHS/DRESS

September 2020 

- Congratulations to María Cottereau for successfully completing her Bachelor´s Thesis with us! 

- New editorial in Allergy: The neuroimmunological toll of nutrient absorption 

August 2020 

- New editorial in Allergy: Thinking small: Zinc sensing by the gut epithelium

July 2020 

- New reviews on SARS-CoV-2 and COVID-19 in Allergy:

A compendium answering 150 questions on COVID-19 and SARS-CoV-2


Immunology of COVID‐19: mechanisms, clinical outcome, diagnostics and perspectives – a report of the European Academy of Allergy and Clinical Immunology (EAACI)

June 2020 

Rodrigo received the EAACI Allergopharma Reserch Award  at the EAACI Annual Congress 2020 where he gave an invited talk entitled "Route of exposure determines the immune response to food allergens"

April 2020 

- Alberto Caminero (McMaster University) and Rodrigo have been awarded a New Frontiers in Research Fund – Exploration 2019 grant

March 2020 

- New article, on B cell biology,  through a collaboration with Ana Cuenda and Yolanda R. Carrasco here at CNB-CSIC:  B Cell Development and T-Dependent Antibody Response Are Regulated by p38γ and p38δ  in Frontiers in Cell & Developmental Biology

New editorial: Follicular T cells: from stability to failure in Allergy 

February 2020 

- New article: Microbial Regulation of Enteric Eosinophils and Its Impact on Tissue Remodeling and Th2 Immunity in Frontiers in Immunology

New editorial: Drug‐induced IgG‐neutrophil‐mediated anaphylaxis in humans: Uncovered! in Allergy 

January 2020 

- Rodrigo has joined the Editorial Board of Allergy!

- Rodrigo attended the 18th Immunology Winter Immunology School in Chamonix (France) as Junior Member Representative of the Immunology Section of EAACI.

  • Twitter



Dept. de Inmunología y Oncología

Centro Nacional de Biotecnología (CNB)

C/ Darwin 3, 28049, Madrid


©2020 by Jiménez-Saiz Lab